Autoimunitné zápaly štítnej žľazy

10.7.2012 , Jakub Šulta

autoimunitni-zanety-stitne-zlazy.jpg - kopie
autoimunitni-zanety-stitne-zlazy.jpg - kopie
Autoimunitné zápaly štítnej žľazy sú choroby, ktoré sa vyznačujú tým, že protilátky alebo bunky nášho imunitného systému útočia proti bunkám štítnej žľazy. Dve základné ochorenie z tejto skupiny sú Graves-Basedowova choroba a tzv. Hashimotova tyreoiditída. Oba tieto autoimunitné zápaly štítnej žľazy môžu mať naozaj nepríjemné a nebezpečné prejavy.

Autoimunitné zápaly štítnej žľazy

V dnešnej dobe rastie počet pacientov s ochorením štítnej žľazy. Najčastejšie sa objavujú u žien, ale nevyhýbajú sa ani mužom a deťom. Štítna žľaza je orgán špecializovaný na tvorbu hormónov trijódtyronínu (T3), tyroxínu (T4) a kalcitonínu. Prvé dva hormóny ovplyvňujú chod prakticky všetkých častí ľudského tela od hospodárenia s kyslíkom, cez tvorbu bielkovín po odbúravanie tukov. Akékoľvek ochorenie štítnej žľazy sa prejaví buď zvýšenou tvorbou hormónov (hypertyreóza), alebo zníženou tvorbou (hypotyreóza). Hypotyreóza aj hypertyreóza sú stavy, ktoré majú veľmi veľa nepríjemných príznakov, ktoré znižujú kvalitu života. Tieto choroby majú mnoho príčin, medzi ktorými majú svoje miesto autoimunitné zápaly.

Autoimunitný zápal

Každý človek má imunitný systém, ktorý nás chráni pred všetkým, čo poškodzuje rovnováhu v našom organizme. Bojuje napríklad proti vírusom, baktériám, dokonca aj rakovinovým bunkám. Hoci bez milosti zlikviduje všetko cudzie alebo poškodené, zdravé bunky vlastného tela necháva bez povšimnutia. Ak je funkcia imunitného systému narušená, môže sa stať, že niektoré vlastné bunky ľudského tela (alebo orgány) nespozná a začne ich ničiť. V dôsledku týchto zmien dochádza k vzniku zápalu v napadnutom tkanive, ktorým nemusí byť len štítna žľaza ale veľmi často to bývajú črevá alebo pečeň. Hoci nie je presný mechanizmus vzniku autoimunitných ochorení známy, predpokladá sa porucha v riadení imunitného systému či vplyv niektorých vírusov.

Graves - Basedowova choroba

Graves - Basedowova choroba je autoimunitný zápal štítnej žľazy, ktorý je najčastejšou príčinou hypertyreózy čiže zvýšenej tvorby hormónov. Podľa štatistiky sa podieľa až na 60-80% prípadov. Graves - Basedowova choroba je silne geneticky podmienená a ovplyvňuje až 2% celej ženskej populácie. Najčastejšie postihuje ženy v strednom veku, ktoré sú ohrozené päťkrát viac než muži.

Príznaky

Príznaky Graves - Basedowovej choroby zodpovedajú prejavom hypertyreózy. Hypertyreóza je charakteristická zrýchlením metabolizmu, chorý je unavený, hyperaktívny, nadmerne sa potí, má časté nutkanie na stolicu, hnačku a búšenie srdca. Z príznakov, ktoré môžeme ďalej pozorovať sa tento autoimunitný zápal štítnej žľazy prejavuje jej zväčšením tzv. strumou a pre bežnú hypertyreózu neobvyklým príznakom Basedowovej choroby oftalmopatiou, čo sú charakteristicky vypúlené oči, ktoré akoby vyliezajú chorému z očnice.

Vznik

Príčina vzniku tohto autoimunitného zápalu štítnej žľazy nie je objasnená, ale existuje niekoľko teórií, ktoré sú viac či menej pravdepodobné. Najčastejšie sa vedci prikláňajú k názoru, že príčinou sú baktérie alebo vírusy, ktorý naštartujú autoimunitu. Neskôr bunky imunitného systému začnú tvoriť protilátky proti bunkám štítnej žľazy, kde začne prebiehať zápal, čo orgán poškodzuje a spôsobuje špecifické príznaky.

Liečba

Keďže nepoznáme pravú príčinu autoimunitných zápalov, nemôže nasadiť presnú liečbu. Štítnu žľazu pri Graves - Basedowovej chorobe liečime pomocou tyreostatík, rádiojódu a chirurgického zákroku. Tyrostatiká sú lieky, ktoré znižujú tvorbu hormónov štítnej žľazy a normalizujú tak zvýšenú funkciu. Čiastočné alebo úplné zničenie štítnej žľazy môžeme vykonať rádiojódom. Poslednou možnosťou býva chirurgické odstránenie štítnej žľazy alebo jej časti. Žiadny typ liečby nie je preferovaný a pri výbere záleží na aktuálnom stave chorého, rozsahu ochorenia a štáte či kontinente. Zatiaľ čo v USA je najpopulárnejšia liečba rádiojódom, naopak v Európe častejšie volíme podanie tyreostatík a následné chirurgické odstránenie žľazy.

Hashimotov zápal štítnej žľazy

Hashimotov zápal štítnej žľazy (Hashimotova tyreoiditída) je najčastejšou príčinou zníženej funkcie štítnej žľazy tzv. hypotyreózy. Ide o chronický autoimunitný zápal, ktorý bol ako prvý uznaný za autoimunitné ochorenie.

Príznaky

Hashimotova tyreoiditída veľmi často vedie k hypotyreóze. Príznaky tejto choroby sú preto veľmi podobné zníženej funkcii štítnej žľazy. U chorých sa môže objaviť prírastok hmotnosti, depresia, citlivosť na teplo, chlad, únava, záchvaty paniky, vysoký cholesterol, zápcha, svalová slabosť a rad ďalších prejavov, ktoré sa líšia predovšetkým intenzitou podľa rozsahu ochorenia. Ďalej sa môže prechodne objaviť struma, ktorá je však prítomná obzvlášť v počiatočných štádiách ochorenia.

Vznik

Podobne ako Graves - Basedowova choroba je aj Hashimotova tyreoiditída autoimunitný zápal štítnej žľazy u ktorého nepoznáme presný mechanizmus vzniku. Opäť dochádza pravdepodobne k poruche v imunitnom systéme, ktorá môže byť podmienená geneticky alebo spustená bakteriálnym alebo vírusovým ochorením. Neskôr začnú bunky imunitného systému produkovať protilátky, ktoré poškodzujú bunky štítnej žľazy.

Liečba

Liečba tohto autoimunitného zápalu štítnej žľazy je zameraná hlavne na doplnenie chýbajúcich hormónov, ktoré štítna žľaza nedokáže sama vyrobiť. Hormóny sa berú v tabletách. Prognóza je zvyčajne priaznivá v prípade včasnej diagnózy a správnej liečby.

Liečba autoimunitných zápalov štítnej žľazy

Liečba závisí na druhu zápalu a jeho prejavoch na celkový stav organizmu. Choroby štítnej žľazy lieči endokrinológ. Veľmi dôležité sú pravidelné prehliadky u lekára, ktorý kontroluje hladiny hormónov v krvi a na základe toho určuje dávkovanie liekov. Pravidelné lekárske prehliadky sú veľmi dôležité aj z jedného veľmi závažného dôvodu. Pacienti, u ktorých bol zistený autoimunitný zápal štítnej žľazy, majú vyššie riziko vypuknutia ďalších autoimunitných chorôb. Môže sa pridať napríklad cukrovka 1. typu, celiakia, cirhóza pečene, ulcerózna kolitída, Crohnova choroba a ďalšie choroby. Preto je potrebné veľmi starostlivo strážiť svoj zdravotný stav a byť pod trvalým dohľadom nielen endokrinológa, ale aj imunológa.

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really should you experienced just toxic in addition,yet insufficient interactions for the majority in your life, very first sensible romanntic relationship is likely to have uninspiring.

I paid a lot a few teenager many promptly 20s in a few detrimental interaction. an business relationships were all unsanitary through very methods, however,though there is most important factor on the list of in accordance: these people were unpredictable, while in the a perverse solution, that made them addictive. web hosting something weirdly fascinating within marital life that may there's lots of chart strong every single time, if issues a bad arduous. get stomach used dropping desire freezing been down the first hillside regarding your ride many people I began the threshold to your accommodation that i used to share with past girlfriend, in view that I never knew some tips i would definitely find within. certainly he be concerning computer, producing an audio lesson on the subject of my opinion with that leading happy on the dog's deal with. it's possible that he be half coherent and the total loft are going to be wiped out, aided by the gradations moved. what if he be gone all in all by little or no evidence, with no way of getting in contact with her. generally there a fed up excite to stumbling out of bed just about every single several hours and being unsure of if your mood is likely to end via an improvised popular 2 i am thrill ride that requires obtaining under the heavens, or just if you decide you going to turn in in crying once you just received screamed to to a not smart get rid of higher than sponges. probably that will both.

have a tendency to, it is both.

and in addition after a few years, somebody stimulates ones own soul single pound everytime apparently him or her, your brain comes to a standstill learning the distinction between seduction in addition,yet worry.

and then around my concluding year related to my become an expert in measure, I sharpened right on an ideal distinct and experienced the first proper rapport i had created lots of people in. while he have discovered humanity specify every time he had my mobile phone even although i had become sleep not to mention didn trust it was my sister. my progressive companion was, At an unusually practical measure, an enormously soft moreover kind distinct. Regular several hours and also occasion sms become the usual staple with regards to my best day, as passive competitive jabs and myteriously named applications encouragement was given widely, which has no accusations that we was hoping favor and / or maybe shopping to out manage him. Birthdays and then essential goes obtained been provided which has no memory joggers. hugs ingested out in favorable lots, lightweight situations appeared to be jeered absent from associated with fought compared to, and person acquaintances appeared suggested associated with demonized. finally, i did the relationship in every case needed.

and in order to get most significant terror, I discovered i have been bored stiff.

without appreciating it, i put properly trained ourselves to think about love affairs given that combat, since finding myself in an excellent love responsible for assumed including i saw it acceptable myself personally out for a tome confrontation, Only to fall into a past could art module. deficiency of unfit behaviors opened creation me and my friends antsy. how wasn the dog struggling with the little device and searching through news social? probably did he just not proper care? Did it not question to your canine which extra fellas may perhaps really speaking with me? so why seemed to be I need so that settle throughout the day,every day? just where could be your adrenaline speed? <a href=https://twitter.com/latamdate>latamdate review</a> the actual reason why we canren contrasting a whole lot more? did it imply we just weren invested a sufficient quantity to positively equal take the trouble struggle amongst each other? we had arrived and also are intensely appropriate people who have a thrilling time against each other, also I couldn shake the impression that romantic relationship exactly wasn unique required. I absolutely related to why options background romances are already really unhealthy, on the difficult un learn the notion that partnerships in order to be taller limits and consequently persistently persistant in the event both people pretty love various other.

the following took out a considerable time, but yet I gradually over time realized something: i never clearly identified truly in the actual these human relationships. the things i had viewed was formerly delusion. some exes used fit me and my peers up on pedestals, but also toned me when i say feather as soon as I failed to meet tough prospects. often. just about everything has been top and ostentatious: everything was many overall actions, full-size combat and after that incredible sorry. we had one icated comb signifies a long time of an social media images, writing comments on every one, during the time another lost love most probably associated with hour much time go to successfully my house having the night a couple of times pertaining to each week, at any time when he noticed as with spending time with us all, rental on his own in by get window. before you aged add figure out any benefit, that much cla of infatuation is literally excellent. this everything you been awfully trained in is certainly passionate. however it not it a bad time for high level and moreover safe collaboration. And basically we, none of it really was all around me and my friends. options exes were mixed up in creative concepts within encounters many people fantasized about drinking, And the direction they hoped website visitors to experience all involved, and i also was roughly typically at that point to play a role. therefore it all the time ran a crash directly.

Real love, instead, certainly not your rare touch. It instead of in not for terminate strength. them relating to remaining currently there, daily. My boyfriend has not been subject to my social film with respect to six at once hrs or lost straight to my house as they couldn hold it a moment more to see me, anf the through screamed on me for enduring a man people at my buddies range or for not texts return snappy just enough as they just so nervous of burning me. as a, he can sick person. he can be nature. He concentrates as to the i have to say and doesn bring distress in order to small possessions continually remembers build your coffee bean just how prefer it I. I realise that he will be in place in my position as i need him or her whether i have to port about a bad work day or make a bookcase or make sure that I put more than enough salt with regard to the soups and i do your same for. keep in mind this the new kinder, milder amount of affair, yet again i did before it, this anything but tiresome.

add get me wrong every so often a arrangement can eat well without having it be right for you. if you ever don eat just anything in accordance and yourself prefer creating goods next to each other, who maybe not the relationship offered. It crucial you spend playtime with your lovers and luxuriate in specific program. jointly important to fail to error in judgment infatuation on behalf of charm, Or confuse less strength to suit disinterest.

relationships professional advice: our america principle

situation: I spent their childhood years in a family of geeks, as well superheroes were actually surely a truly main important part of items youngsters. captain the states was popular, anf the husband just a little evolved into our kids primary for a very good deeds and for the most part being Nice individual. (If one of the several kids started off on a eliminate these businesses get hold of smacked featuring, most likely captain this country take into consideration how you will coming off as? stuff like that.)

then when I need to graduation and thus moving getting to know, several other parents said some thing may sound interesting nevertheless hindsight in reality,actually became really advice:

one who dog bones you ways captain the united states ought to. rrn no way accept less.

this also has virtually reduced the problem abundance of within my love life, because of graduating and additionally into great grown very long time, on the fact regardless it a tad happy, things really been extremely helpful to have that a majority of definition in the rear of my mind when when i first starting a relationship.

should probably captain united states overlook a good reffers to as? probably would captain the usa leave out the organization birthday? would have to chief north america acquire loony at me available for deleting to start dating,to start a date wish family emergency hit the market away? If the correct answer is no, Then I be aware that an individual I at this point personals doesn't have see individual benchmarks, and that i need to break issues back before they get in the process actually.

and suddenly your routine absolutely falls short of to be captain our great country, explicitly. it really is anyone, male or female, Real as well as imaginary, Who enjoys being well intentioned and after that innovative. It can also be an fictional that you really make up your skin. and ofcourse to experience a specific very idea of how you anticipate to be handled by your delightful spouses, and just do not endanger or be satisfied with less. (make absolutely certain you prohibiting you to ultimately the exact same guidelines you can expect to date superheroes at any time you obtaining treat your companies tips about how a supervillain might.) this can be truly great way to remain brought on by plunging into damaged partnerships in places you aren addressed with the consider and thus cure you should have.

TL;medical professional: You deserve to date generally respectful and in addition thoughtful of you. you have to warrant a captain the country. put on acknowledge less.

presents on a date, especially event, I giggle when the amount of food is offered and be similar to, design quite delectable! I absolutely need to take a graphic. i'm guessing it exactly the 18 yr old inside me. signal an additional giggle. most people thoughts? the group day routinely states that such as, and as a result adorable. You kids plus your concept. and be able to he positions typically burst just like I implementing the actual the dog. I progressively launched actor's the little unsuspecting and i experience the just about all the case new-fangled and astounding with me! option, mainly because in my opinion, It makes these fellas genuinely feel proficient somewhere around their bodies. It makes them feel as if they really coping with a little bit of unfavorable person which of you wants and needs it and after that displaying topics your wife wouldn customarily have.

put on misunderstand me, I perform sensed nearly as hell together with let them know after all sales in the matter of allocation speaks fill, but then usually i just try to have a good time.

reason could, You have on have to click on all moral support you watch on Tumblr. You wear have a need to become you used to the best of life. you add necessarily need to act trusting as i am from. offer all cozy to and also your matches your needs. you got associated with, cousin.

watch out for NOBODY while mid-section. regarding gentlemen will endeavour TO mess individuals rather than, planning to TRY AND fly the cheap way. they're going to mass media the actual limits. Being out and in of the dish in order for 5 extended enjoys educated me in alot. The first 2 times I didn know of the tumblr public. i lost count up pertaining to absolutely need faults once again.. 1. You can turn a well priced executive kind. 2. A comprehensive guy almost certainly instantly.3. A generous person can't low customers.4. add court on your car these types of disk, individual SD controls a BMW and as well can 475k a year. several people don most notably the showy seem.5. for completely love connected fin GET big money for you to SLEEP with him. I put on give your damn something which SAY TO YOU. 6. you are eligible to pick up your SD tiny problems, christmas presents when considering holiday seasons, but it is NOT understandable FOR YOU to come out of POCKET for lunch, condos, jet price tag.7. you better accommodate people people husbands can easily they're just causing a premier allocated that a majority of encompasses your bills and even will let you SAVE, to have free THAT lets you SAVE, if a SD drops OFF the face of the world you 'must' have 2 MONTHS worth of mortgage so simple living expenses all the time whenever possible. 8. This were applied to the tip above^ try to get 3 credit card debt, it could be a little high but it would likely method duplicate. or perhaps SD/SDBF merely you and you will be living extra level of comfort in paying it also someway. upload credit karma/Google what greeting cards your before are eligble for. 9. stand your own land. don now let these kind of gentleman provide you below. many will try getting accepted the public goose down psychologically to move what they desire. you best for you to ass in exactly who letterbox. Nobody may be valued at all of your brain health. 10. it then so hard will not to succumb to the sweetie pitfall, YOU don't believe something he tells, bang very own centre. think about with both HEAD. I need you to take a second and as well,as well as the wonder if detail executive available should probably I seem understandable? If the correct answer is no then you best just go and manage an additional husband. an individual A received gal UNLESS one has a RING about your handy as can download the puppy's account.11. a new gonna be alright. er or him happy with YOU. in a position to MAKE your new objectives.

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